pICIn Mouse, Unlabeled, Clone: 32, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611274
pICln (I = current, Cl = chloride, n = nucleotide-sensitive) was initially described as an integral component of a nucleotide-sensitive chloride channel. However, it lacks homology to known channel proteins and exhibits cytoplasmic and nuclear localization. Thus, pICln is thought to be a cytosolic regulator of a swelling-induced chloride channel, rather than a component of a channel itself. In support of this hypothesis, pICln interacts with several cytosolic proteins. It binds to several Sm proteins, which are common spliceosomal core proteins whose assembly
is necessary for the biogenesis of small nuclear ribonucleoproteins (snRNPs). Sm protein association with pICln inhibits their assembly. pICln also interacts with the 72kDa human homolog of Skb1, a yeast protein that binds a homolog of p21[Cdc42/Rac]-activated protein kinases. In addition, pICln interacts with, and is phosphorylated by, a constitutively active cytosolic protein kinase. Therefore, pICln is thought to be a component of signaling pathways that function in transcriptional or translational regulation, cytoskeletal reorganization, or a number of other biological processes.
Host Species: Mouse
Species Reactivity: Human
Immunogen: Human pICln aa. 92-201
Formula Weight [Chemical]: 37/42kDa
Immunofluorescence, Western Blotting
|Canine, Human, Murine, Rat|
|Immunofluorescence, Western Blot|
|Human pICln aa. 92-201|
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