PICK1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA513841

Catalog No. PIPA513841

Description

This antibody is predicted to react with bovine, non-human primate and rat based on sequence homology.

PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKC alpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKC alpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKC alpha to membrane anchored GluR2. Once phosphorylated by PKC alpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.

Specifications

• Antigen: PICK1
• Classification: Polyclonal
• Gene: PICK1
• Gene Alias: PRKCA-binding protein; Protein kinase C-alpha binding protein; Protein interacting with C kinase 1; PICK1
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 18693, 9463
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: Q9NRD5, Q62083
• Gene Symbols: PICK1
• Immunogen: KLH conjugated synthetic peptide between 286-316 amino acids from the C-terminal region of human PICK1 (PRKCABP)
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG