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PIP5K1A Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA515281

Catalog No. PIPA515281

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Overexpression of phosphatidylinositol phosphate 5-kinase alpha (PIP5KIalpha), which synthesizes PIP2, suppresses apoptosis, whereas a kinase-deficient mutant does not. Protection by the wild-type PIP5KIalpha isaccompanied by decreases in the generation of activated caspases and of caspase 3-cleaved PARP. Protection is not mediated through PIP3 or Akt activation. An anti-apoptotic role for PIP(2) is substantiated by the finding that PIP5KIalpha is cleaved by caspase 3 during apoptosis, and cleavage inactivates PIP5KIalpha in vitro. Mutation of the P(4) position (D279A) of the PIP5KIalpha caspase 3 cleavage consensus prevents cleavage in vitro, and during apoptosis in vivo. Significantly, the caspase 3-resistant PIP5KIalpha mutant is more effective in suppressing apoptosis than the wild-type kinase. PIP2 is a direct regulator of apical and effector caspases in the death receptor and mitochondrial pathways, and PIP5KIalpha inactivation contributes to the progression of apoptosis.
Specifications

Specifications

PIP5K1A
Polyclonal
PBS with 0.09% sodium azide
Q99755
Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; PtdIns(4)P-5-kinase alpha; PIP5KIalpha; Phosphatidylinositol-4-phosphate 5-kinase type I alpha; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha; PIP5K1A
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8394
Western Blot
Unconjugated
PIP5K1A
Liquid
PIP5K1A
KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human PIP5K1A
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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