PIR-A/PIR-B Rat anti-Mouse, Clone: 404127, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA524140
Reconstitute at 0.5 mg/mL in sterile PBS.Paired Ig-like receptors of activating (PIR)-A and -B are expressed on B lymphocytes, macrophages, dendritic cells, platelets, granulocytes, and mast cells, but not on T cells, NK cells, and erythrocytes. These cell surface glycoproteins contain six extracellular Ig-like domains with distinct cytoplasmic and transmembrane regions. The PIR-A receptor activates through signaling molecules containing immunoreceptor tyrosine-based activation motifs. In contrast, the PIR-B receptor inhibits through proteins possessing immunoreceptor tyrosine-based inhibitory motifs. PIRs bind MHC class I to modulate immune system homeostasis and cell signaling.
|PBS with 5% trehalose and No Preservative|
|pirb, Leukocyte immunoglobulin-like receptor subfamily B member 3, LIR-3, Leukocyte immunoglobulin-like receptor 3, Cell-surface glycoprotein p91, Paired immunoglobulin-like receptor B, PIR-B, Lilrb3, Pirb, Leukocyte immunoglobulin-like receptor subfamily B member 4, Mast cell surface glycoprotein Gp49B, CD85k, Lilrb4, Gp49b, Pira1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Mouse myeloma cell line NS0-derived recombit mouse PIR-A1 Gly24-Met650|
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