Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

PITP Mouse, Unlabeled, Clone: 50, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611024

Catalog No. BDB611024

Add to cart



PITP (Phosphatidylinositol Transfer Protein) is an abundant cytosolic protein that is required for phospholipase C (PLC) signaling and vesicular trafficking. Mammalian cells contain the two PITP isoforms α and β, which bind to lipids with different affinities. PITPα contains a single lipid-binding site and reversibly binds phosphatidylinositol (PtdIns) and phosphatidylcholine (PC), then transfers them between membrane compartments. PITPα exhibits a much higher affinity for PtdIns than for PC. PITPα and β participate in PLC signaling, mediated by the ability of PITP to deliver PtdIns to the signaling complex containing PI4-Kinase, PIP5-Kinase, and the activated receptor. A retroposon insertion in the murine gene encoding PITPα interferes with RNA accumulation and is thought to be the primary cause of the mouse vibrator mutation, a neurodegenerative disorder. Thus, PITP mediates the intracellular transfer of phospholipids, which is central to processes such as PLC signaling, exocytosis, and secretory vesicle formation. More importantly, PITPα and PtdIns signaling pathways, in general, may be critical targets in mammalian neurodegenerative disorders. Due to high homology levels between the PITPα and β isoforms, this antibody may cross react with PITPβ.

Immunofluorescence, Western Blotting



Canine, Human, Murine, Rabbit, Rat
Immunofluorescence, Western Blot
Affinity Purified
Human PITPα aa. 143-264
Cell Biology
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit