PITP Mouse, Unlabeled, Clone: 50, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611024
PITP (Phosphatidylinositol Transfer Protein) is an abundant cytosolic protein that is required for phospholipase C (PLC) signaling and vesicular trafficking. Mammalian cells contain the two PITP isoforms α and β, which bind to lipids with different affinities. PITPα contains a single lipid-binding site and reversibly binds phosphatidylinositol (PtdIns) and phosphatidylcholine (PC), then transfers them between membrane compartments. PITPα exhibits a much higher affinity for PtdIns than for PC. PITPα and β participate in PLC signaling, mediated by the ability of PITP to deliver PtdIns to the signaling complex containing PI4-Kinase, PIP5-Kinase, and the activated receptor. A retroposon insertion in the murine gene encoding PITPα interferes with RNA accumulation and is thought to be the primary cause of the mouse vibrator mutation, a neurodegenerative disorder. Thus, PITP mediates the intracellular transfer of phospholipids, which is central to processes such as PLC signaling, exocytosis, and secretory vesicle formation. More importantly, PITPα and PtdIns signaling pathways, in general, may be critical targets in mammalian neurodegenerative disorders. Due to high homology levels between the PITPα and β isoforms, this antibody may cross react with PITPβ.
Immunofluorescence, Western Blotting
|Canine, Human, Murine, Rabbit, Rat|
|Immunofluorescence, Western Blot|
|Human PITPα aa. 143-264|
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