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PRKAR2B Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528266

Catalog No. PIPA528266


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Description

Description

PA5-28266 targets PKA 2 beta in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples. The PA5-28266 immunogen is recombit fragment corresponding to a region within amino acids 177 and 391 of Human PKA 2 beta. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
Specifications

Specifications

PRKAR2B
Polyclonal
Unconjugated
PRKAR2B
Liquid
PRKAR2B
Recombit fragment corresponding to a region within amino acids 177 and 391 of Human PKA 2 beta
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.67 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P31323, P31324
PRKAR2, RII-BETA, H_RG363E19.2, WUGSC:H_RG363E19.2, cAMP-dependent protein kinase type II-beta regulatory chain, cAMP-dependent protein kinase type II-beta regulatory subunit
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
19088, 5577
Documents
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