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PKA(RIα) Mouse, Unlabeled, Clone: 20, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 610610
Description
cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ. These subunits define type I and II cAMP-dependent protein kinases. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and type II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ). Type II PKA can be distinguished by autophosphorylation of the R-subunits, while type I PKA binds Mg/ATP with high affinity. Most cells express both type I and type II PKAs. Although the Rα isoforms are ubiquitously expressed, the Rβ isoforms are predominant in nervous and adipose tissues. Expression of the RIβ subunit is modulated during muscle and adipocyte differentiation in vitro.
Immunofluorescence, Immunoprecipitation, Western Blotting
Specifications
PKA(RIα) | |
Monoclonal | |
250μg/mL | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
Human PKA [RIα] aa. 1-381 | |
150 μg | |
Cell Biology | |
Canine, Chicken, Human, Mouse, Rat | |
IgG1 |
Western Blot | |
20 | |
Unconjugated | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at -20°C. |
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For Research Use Only.