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PKA(RIα) Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

$225.00 - $415.00

Specifications

Antigen PKA(RIα)
Isotype IgG1
Immunogen Human PKA [RIα] aa. 1-381
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610609
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BD Biosciences
610609
50μg
Each for $225.00
Add to cart
 
BDB610610
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BD Biosciences
610610
150μg
Each for $415.00
Add to cart
 
Description

Description

cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ. These subunits define type I and II cAMP-dependent protein kinases. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and type II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ). Type II PKA can be distinguished by autophosphorylation of the R-subunits, while type I PKA binds Mg/ATP with high affinity. Most cells express both type I and type II PKAs. Although the Rα isoforms are ubiquitously expressed, the Rβ isoforms are predominant in nervous and adipose tissues. Expression of the RIβ subunit is modulated during muscle and adipocyte differentiation in vitro.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

PKA(RIα)
Human PKA [RIα] aa. 1-381
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
20
250μg/mL
SDS

For Research Use Only.

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