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PKC beta-1,2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513740

Catalog No. PIPA513740

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3 ft. end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.
Specifications

Specifications

PKC beta-1,2
Polyclonal
PBS with 0.09% sodium azide
P05771
Protein kinase C, beta type; PRKCB1; PRKCB; PKCB
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5579
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
PRKCB
Liquid
PRKCB
KLH conjugated synthetic peptide between 303-334 amino acids from the central region of human PKC beta1/2
Protein A
RUO
Antibody
Polyclonal
Human
Documents
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