PKC lambda/iota, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527811
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.PA5-27811 targets PKC iota in IF, IHC (P), and WB applications and shows reactivity with Human samples.The PA5-27811 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 233 of Human PKC iota.
|Recombinant fragment corresponding to a region within amino acids 1 and 233 of Human PKC iota|
|Antigen affinity chromatography|
|Store at -20°C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|DXS1179E, PKCI, nPKC-iota, PRKC-lambda/iota, aPKC-lambda/iota, atypical protein kinase C-lambda/iota, protein kinase C iota type|
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