PKN1 Mouse anti-Human, Clone: 1B10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA519703
Peptide Sequence: LDMEPQGCLV AEVTFRNPVI ERIPRLRRQK KIFSKQQGKA FQRARQMNID VATWVRLLRR LIPNATGTGT FSPGASPGSE ARTTGDISVE KLNLGTDSDS SPQKSSRDPP SSPSSLSSPI QESTAPELPS ETQETPGPAL CSPLRKSPLT LEDFThe protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
|PBS with no preservative; pH 7.4|
|Serine/threonine-protein kinase N1, Protease-activated kinase 1, PAK-1, Protein kinase C-like 1, Protein kinase C-like PKN, Protein kinase PKN-alpha, Protein-kinase C-related kinase 1, Serine-threonine protein kinase N, PKN1, PAK1, PKN, PRK1, PRKCL1|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|PKN1 (AAH40061, 462 a.a. ∽ 615 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
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