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PKR Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1991

Catalog No. PA1991


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Description

Description

PA1-991 detects PKR in human and mouse samples. PA1-991 has been successfully used in Western blot and ICC/IF procedures. In Western blot analysis of HeLa cell cytosol this antibody detects a ~66 kDa protein representing PKR. The PA1-991 immunogen is a synthetic peptide corresponding to residues K(358) T K C L F I Q M E F C D K G(372) of human PKR.

PKR is a 68 kDa protein and an IFN-induced serine/threonine protein kinase consisting of two N-terminal RNA-binding regulatory domains and a functional C-terminal serine/threonine protein kinase domain. Activated by dsRNA produced during viral infections, PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. Upon activation, PKR gets autophosphorylated and catalyzes the phosphorylation of elF2 alpha subunit, which leads to an inhibition of protein synthesis. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & maligcy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
Specifications

Specifications

PKR
Polyclonal
Unconjugated
EIF2AK2
Liquid
EIF2AK2
Synthetic peptide corresponding to residues K(358) T K C L F I Q M E F C D K G(372) of human PKR.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P19525, Q03963
Protein Kinase R, eIF2a Kinase, ds RNA-Dependent Protein Kinase
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
19106, 5610
Documents
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