PLD2 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523335
DescriptionPLD2 is a peripheral membrane protein belonging to phospholipase D family with a PH domain, two PLD phosphodiesterase domains and a PX (phox homology) domain that plays a regulatory rather than catalytic role. PLD2 catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid and choline. PLD2 may function in regulated secretion, signal-induced cytoskeletal regulation and/or endocytosis, transcriptional regulation, and cell cycle control. It is usually stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and activated by the ADP-ribosylation factor-1 (ARF-1). PLD2 is activated by agonist stimulation of both tyrosine kinase and G protein-coupled receptors and is also known to interact with EGFR and PIP5K1A. PLD2, localized to plasma membrane caveolae, is ubiquitously expressed in most tissues.
|whole serum with 50% glycerol and 0.025% sodium azide|
|PLD1C, choline phosphatase 2, hPLD2, phosphatidylcholine-hydrolyzing phospholipase D2|
|Human, Non-human Primate|
|Immunohistochemistry (Paraffin), Western Blot|
|Amino acids 199-216 DLGRKGLEGMIRKRSGGH of human PLD2 protein were used as the immunogen.|
|-20° C, Avoid Freeze/Thaw Cycles|
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