Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Plectin Mouse anti-Human, Unlabeled, Clone: 31, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611348

Catalog No. BDB611348


Add to cart

Description

Description

Plectin is an intermediate filament-binding protein that acts as a cross-linking elementin the cytoskeleton. Sequence analysis reveals that plectin is dumbbell shaped and contains a long central α-helical coiled-coil rod flanked by globular domains. Plectinhas six C-terminal repeats that exhibit a tandemLy repeated amino acid sequence motif that is characteristic of intermediate filament-associated proteins, such as BPAG1 and desmoplakin. Plectin associates with the sarcolemma, nuclear membrane, and intermyofibrillar network in muscle and with hemidesmosmes in skin. These localizations may be a result of plectin binding to a variety of cytoskeletal proteins including laminin B, microtubule-associated proteins, and α-spectrin. In addition, plectin interacts with G-actin in a PIP2-dependent manner and with actin stress fibers viaits N-terminal actin-binding domain. Patients with epidermolysis bullosa simplex, adisease that results in structural and functional abnormalities in muscle and skin, have no plectin expression in muscle tissues and deficient plectin levels in skin. Thus, plectin cytoskeletal association may be critical for the structural integrity of muscle and skin.

Host Species: Mouse
Clone: 31
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Plectin aa. 3062-3184
Formula Weight [Chemical]: 400/500kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Plectin
31
Unconjugated
Affinity Purified
Human Plectin aa. 3062-3184
50μg
Cell Biology
Primary
Human
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit