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PLEKHM3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520851

Catalog No. PIPA520851


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Description

Description

A suggested positive control is mouse skeletal muscle tissue lysate. PA5-20851 can be used with blocking peptide PEP-0965.

PLEKHM3, also known as DAPR, is a member of the M family of Pleckstrin homology domain-containing proteins. PLEKHM3 was initially identified through chromatin immunoprecipitation and CpG microarray analysis examining proteins regulated by myocyte-enhancing factor 2. In C2C12 myoblast cells, PLEKHM3 binds to the PI3K signaling member protein kinase B in the cytosol prior to differentiation into myotubes. Following the initiation of differentiation, PLEKHM3 was also found in membrane fractions. Knockdown of PLEKHM3 expression by RNAi resulted in the inhibition of myotube formation, suggesting that PLEKHM3 is a key component required by myoblasts for orchestrating their differentiation during myogenesis.
Specifications

Specifications

PLEKHM3
Polyclonal
Unconjugated
PLEKHM3
Liquid
PLEKHM3
A 13 amino acid peptide from near the carboxy terminus of human PLEKHM3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q6ZWE6, Q8BM47
DAPR, PLEKHM1L; PH domain-containing family M member 3; differentiation associated protein; pleckstrin homology domain-containing family M member 3
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
241075, 316455, 389072
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