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PLK1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528023

Catalog No. PIPA528023


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Description

Description

PA5-28023 targets PLK1 in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-28023 immunogen is recombit fragment corresponding to a region within amino acids 161 and 470 of Human PLK1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.
Specifications

Specifications

PLK1
Polyclonal
Unconjugated
PLK1
Liquid
PLK1
Recombit fragment corresponding to a region within amino acids 161 and 470 of Human PLK1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P53350
PLK, STPK13, PLK-1, cell cycle regulated protein kinase, polo (Drosophia)-like kinase, polo like kinase, serine/threonine-protein kinase 13, serine/threonine-protein kinase PLK1
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
5347
Documents
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