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PODXL Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA146169

Catalog No. PA146169


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Description

Description

This immunogen should be sufficiently distant from any glycosylation site. Suggested positive control: human lung protein.

Podocalyxin (PODXL) is an extensively N/O-glycosylated and sialylated type I transmembrane protein that contains C-terminal PDZ-binding motif DTHL capable of facilitating interactions with NHERF1/NHERF2 adaptor proteins which complexes with proteins implicated in ion transport, protein trafficking and signal transduction. PODXL function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in podocytes by charge repulsion. PODXL also acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. It induces apical actin-dependent microvilli formation and is implicated preapical plasma membrane subdomain formation to set up inital epithelial polarization and apical lumen formation during renal tubulogenesis. PODXL is highly expressed in renal glomeruli, embryonic germ layers, hematopoietic progenitors, megakaryocytes and platelets, vascular endothelia, mesothelial cells lining organs, and neurons. In several maligcies such as leukemia and cancer of breast, testicular, prostate etc, PODXL interactions with actin-binding protein EZR enhances cancer aggressiveness by inducing cell migration and invasion through via modulation of MAPK/PI3K signaling.
Specifications

Specifications

PODXL
Polyclonal
Unconjugated
PODXL
Liquid
PODXL
Human Podocalyxin protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
0.90 mg/mL
tris glycine with 0.15M NaCl and 0.05% sodium azide
O00592, Q9R0M4
PODLX2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
27205, 5420
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