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Podoplanin Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511875

Catalog No. PIPA511875

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
Specifications

Specifications

Podoplanin
Polyclonal
PBS with 0.09% sodium azide
Q86YL7
GP36, HT1A-1, hT1a-1, lung type-I cell membrane-associated glycoprotein, podoplanin
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10630
Western Blot
Unconjugated
PDPN
Liquid
PDPN
KLH conjugated synthetic peptide between 33-63 amino acids from the N-terminal region of human Podoplanin / GP36 / T1A-2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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