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PON3 Rat anti-Human, Mouse, Rat, Clone: 454929, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524173

Catalog No. PIMA524173


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Description

Description

This antibody detects endogenous human, mouse, and rat PON3 in Western blots. In Western blots, this antibody does not cross-react with Recombinant human (rh) PON1 or rhPON2. Reconstitute at 0.5 mg/mL in sterile PBS.

Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase that is tightly associated with apoA-I in HDL. PON1 prevents the oxidation of LDL, thereby the formation of atherogenic oxidised-LDL. Polymorphisms of the human PON1 gene are correlated with coronary artery disease, indicating a genetic association between PON1 and coronary artery disease. PON1 activity is lower in subjects prone to development of atherosclerosis such as in type 1 and type 2 diabetes, familial hypercholesterolemia, and renal disease, indicating the involvement of PON1 in atherosclerosis development. PON2 is a ubiquitously expressed intracellular protein that can protect cells against oxidative damage. PON3 is similar to PON1 in activity but differs from it in substrate specificity. PON1 and PON3 are implicated in lowering the risk of developing coronary artery disease and atherosclerosis. Human PON3 protein shares the 3 conserved cysteine residues identified in PON1, suggesting their importance of in vivo activities. PON1-based catalytic scavengers can be a way to safe and effective organophosphate intoxication.
Specifications

Specifications

PON3
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q15166, Q62087, Q68FP2
Serum paraoxonase/lactonase 3
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
269823, 312086, 5446
Western Blot
454929
Unconjugated
PON3
Lyophilized
PON3
E. coli-derived recombit human PON3 Ala30-Leu354
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
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