KV2.2 (KCNB2) Rabbit anti-Mouse, Rat, Xenopus laevis, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112750
This antibody is specific for the ~125k voltage gated potassium channel, Kv 2.2 subunit. A suggested positive control for this product is rat brain lysate.Kcnb2 (Kv2.2) encodes a Voltage-gated K+ channel which are important determits of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variation in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK) channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cell types including pancreatic islet , alveolar cells and cardiac myocytes. Kv2.1 and Kcnb2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells. Functionally, Kcnb2 mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Diseases associated with KCNB2 include Brugada Syndrome.
|HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|-20° C, Avoid Freeze/Thaw Cycles|
|117105, 373827, 98741|
|Immunohistochemistry, Western Blot|
|Synthetic peptide from rat voltage gated potassium channel, Kv2.2-subunit conjugated to KLH|
|Antigen affinity chromatography|
|Mouse, Rat, Xenopus laevis|
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