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KV2.2 (KCNB2) Rabbit anti-Rat, Xenopus laevis, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14666

Catalog No. PA14666


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Description

Description

This antibody is specific for the ~125 kDa Kv 2.

Kcnb2 (Kv2.2) encodes a Voltage-gated K+ channel which are important determits of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variation in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK) channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cell types including pancreatic islet , alveolar cells and cardiac myocytes. Kv2.1 and Kcnb2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells. Functionally, Kcnb2 mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Diseases associated with KCNB2 include Brugada Syndrome.
Specifications

Specifications

KV2.2 (KCNB2)
Polyclonal
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Q63099
delayed rectifier potassium channel protein, KCNB2, potassium channel Kv2.2, potassium voltage-gated channel subfamily B member 2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
117105, 373827
Immunohistochemistry, Western Blot
Unconjugated
Kcnb2
Liquid
Kcnb2, kcnb2.L
Synthetic peptide corresponding to amino acid residues specific to the Kv2.2 subunit of rat KCNB2 conjugated to KLH
Affinity chromatography
RUO
Antibody
Polyclonal
Rat, Xenopus laevis
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