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KV4.2 (KCND2) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112660

Catalog No. 01-674-815


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Description

Description

The Kv4.2 potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the Shal potassium channel subfamily. Potassium channels are mainly found in plasma membranes but are not generally distributed over the cell surface. Potassium channels catalyze the rapid permeation of potassium ions while rejecting biologically abundant potential competitors such as sodium, calcium and magnesium. Ion selectivity and high through put rate of potassium channels is accomplished by precise co-ordination of dehydrated potassium by the protein and multiple ion occupancy within the permeation pathway. All potassium channels carry out the formation of a transmembrane leak specific for potassium ions. Since cells almost universally maintain cytoplasmic potassium concentrations higher than those extracellularly, the opening of a potassium channel implies a negative ongoing change in electrical voltage across the cell membrane. This may result in termination of the action potential of electrically excitable cells including nerve, muscle and pancreatic beta cells. In non–excitable cells, potassium channels play important roles in the cellular potassium recycling required for electrolyte balance effected by the renal epithelium.
Specifications

Specifications

KV4.2 (KCND2)
Polyclonal
Unconjugated
KCND2
Liquid
KCND2
Synthetic peptide derived from the rat Kv4.2 potassium channel conjugated to KLH.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.08% sodium azide
Q9NZV8, Q9Z0V2, Q63881
Kv4.2, RK5, Shal1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16508, 3751, 65180
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