PPAPDC1A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520864
A suggested positive control is human brain tissue lysate. PA5-20864 can be used with blocking peptide PEP-0978.Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide(NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. PPAPDC1A is preferentially expressed in endothelial cells. Studies of PPAPDC1A and PAP activity suggest that they may play a role in angiogenesis.
|A 14 amino acid peptide near the carboxy terminus of human PPAPDC1A.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|RP11-257O17.1, DPPL2, PPAPDC1; diacylglycerol pyrophosphate like 2; phosphatidate phosphatase PPAPDC1A; phosphatidic acid phosphatase type 2 domain-containing protein 1A|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|196051, 309014, 381925|
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