PPAPDC1B Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520881
A suggested positive control is EL4 cell lysate. PA5-20881 can be used with blocking peptide PEP-0995.Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide (NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. Knockdown experiments indicated that this protein is involved with multiple cell signaling pathways, including the JAK-Stat3, MAP kinase, and PKC pathways. PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22.
|A 14 amino acid peptide near the amino terminus of human PPAPDC1B.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|DPPL1, HTPAP; diacylglycerol pyrophosphate like 1; phosphatidate phosphatase PPAPDC1B; phosphatidic acid phosphatase type 2 domain-containing protein 1B|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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