PPAR delta Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA186845
Predicted to react with chimpanzee, mouse, rabbit and rat based on sequence homology. In Western blots, a band at ~55 kDa is detected from heart whole cell lysates. Rabbit anti PPRAD antibody detects peroxisome proliferator-activated receptor, delta (PPARD), a member of the nuclear hormone receptor subfamily.Peroxisome proliferator-activated receptor delta (PPARD) is a member of the nuclear hormone receptor subfamily. Upon activation, PPARA forms heterodimers with retinoid X receptors (RXRs), and functions to regulatetranscrption of specific gene sequences. In particular, PPARA controls genes involved in the peroxisomal and mitochondrial beta oxidation pathways, fatty acid uptake, and triglyceride catabolism in the liver and skeletal muscle. PPARA also has anti-inflammatory and anti-proliferative effects and prevents the proatherogenic effects of cholesterol accumulation in macrophages by stimulating cholesterol efflux. PPARA is the main target of fibrate drugs; hypolipidemic agents used in the treatment of dyslipidemia and the prevention of cardiovascular disease. They could also be used for the treatment of type II diabetes.
|4°C or -20°C if preferred|
|ELISA, Western Blot|
|PBS with 0.09% sodium azide; pH 7.2|
|synthetic peptide corresponding to amino acids 1-14 of mouse PPAR delta.|
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