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PPAR alpha/gamma Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA3820

Catalog No. PA3820


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Description

Description

PA3-820 detects peroxisome proliferator activated receptor (PPAR) gamma 2 from human, mouse, and rat tissues and cells. PA3-820 has been successfully used in Western blot, immunoprecipitation and gel shift procedures. By Western blot, this antibody detects an ~55 kDa protein representing PPAR gamma2 from 3T3-L1 cell lysate. PA3-820 immunizing peptide corresponds to amino acid residues 484-498 from rat PPAR gamma2. This sequence is completely conserved in bovine, chicken, human, mouse, pig and rat PPAR gamma1, PPAR alpha and NUC1.

Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR’s). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR’s are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPAR’s can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. PPAR, like several other nuclear hormone receptors, heterodimerizes with retinoid X receptor (RXR) alpha.
Specifications

Specifications

PPAR alpha/gamma
Polyclonal
whole serum diluted in PBS with 0.05% sodium azide
P37231, Q07869, P23204, P37238, O88275, P37230
Peroxisome Proliferator Activated Receptor
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Gel Shift, Immunoprecipitation, Western Blot
Unconjugated
PPARA
Liquid
PPARA, PPARG
Synthetic Peptide: I(484) K K T E T D M S L H P L L Q(498)
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
19013, 19016, 25664, 25747, 5465, 5468
Documents
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