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PPP4C Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528786

Catalog No. PIPA528786


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Description

Description

PA5-28786 targets PPP4C in WB applications and shows reactivity with Human samples. The PA5-28786 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 45 of Human PPP4C. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.
Specifications

Specifications

PPP4C
Polyclonal
Unconjugated
PPP4C
Liquid
PPP4C
Synthetic peptide corresponding to a region within amino acids 1 and 45 of Human PPP4C
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.45 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P60510
PP4, PP4C, PPH3, PPP4, PPX, PP-X, protein phosphatase 4 (formerly X), catalytic subunit, protein phosphatase X, catalytic subunit, serine/threonine-protein phosphatase 4 catalytic subunit
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
5531
Documents
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