PPP4C Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528786
PA5-28786 targets PPP4C in WB applications and shows reactivity with Human samples. The PA5-28786 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 45 of Human PPP4C. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.
|Synthetic peptide corresponding to a region within amino acids 1 and 45 of Human PPP4C|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|PP4, PP4C, PPH3, PPP4, PPX, PP-X, protein phosphatase 4 (formerly X), catalytic subunit, protein phosphatase X, catalytic subunit, serine/threonine-protein phosphatase 4 catalytic subunit|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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