Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Prekallikrein Heavy Chain Mouse anti-Human, Non-human primate, Clone: 13G11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA110830

Catalog No. 01-671-858


Add to cart

Description

Description

MA1-10830 detects Prekallikrein, heavy chain, from human, chimpanzee, baboon, and rhesus monkey samples. MA1-10830 has been successfully used in ELISA and Western blot applications. The MA1-10830 immunogen is Human plasma prekallikrein.

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
Specifications

Specifications

Prekallikrein Heavy Chain
Monoclonal
0.61 mg/mL
PBS with no preservative; pH 7.4
P03952
KLK3, PPK
Mouse
IgG1
200 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3818
ELISA, Western Blot
13G11
Unconjugated
KLKB1
Liquid
KLKB1
Human plasma prekallikrein.
Protein G
RUO
Antibody
Monoclonal
Human, Non-human Primate
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit