Prekallikrein Heavy Chain Mouse anti-Human, Non-human primate, Clone: 13G11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA110830
MA1-10830 detects Prekallikrein, heavy chain, from human, chimpanzee, baboon, and rhesus monkey samples. MA1-10830 has been successfully used in ELISA and Western blot applications. The MA1-10830 immunogen is Human plasma prekallikrein.Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
|Prekallikrein Heavy Chain|
|PBS with no preservative; pH 7.4|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|Human plasma prekallikrein.|
|Human, Non-human Primate|
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