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Presenilin 1 Chicken anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Chicken Polyclonal Antibody

Manufacturer:  Invitrogen PA11752

Catalog No. PA11752

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PA1-1752 detects presenilin 1 protein (PS1) from human, rat and mouse samples. PA1-1752 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~66 kDa protein representing PS1. The PA1-1752 immunogen is a synthetic peptides corresponding to residues K(311) N S K Y N A E S T E R(322) and E(342) A Q R D S H L G P H R(353) of human PS1.

Familial Alzheimer’s disease is often characterized by an early (<60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. Recent studies have linked mutations in presenilin 1 (PS1) and presenilin 2 (PS2) to a rapid increase in plaque accumulation. PS1 and PS2 are integral membrane proteins that contain 6-8 transmembrane domains and are predomitly localized within the endoplasmic reticulum and Golgi of neurons within the brain. Within the transmembrane regions of PS1 and PS2 there is over 60% homology, with the largest divergence found at the N-terminus and large loop region.

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly



Presenilin 1
Mixture of synthetic peptides corresponding to residues K(311) N S K Y N A E S T E R(322) and E(342) A Q R D S H L G P H R(353) of human PS1.
PEG precipitation
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.02% sodium azide
P49768, P49769, P97887
PS1, PS-1, S182 protein
100 μg
-20° C, Avoid Freeze/Thaw Cycles
19164, 29192, 5663
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