AMPK alpha-2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA525987
This antibody is predicted to react with mouse, porcine and rat based on sequence homology.The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
|PBS with 0.09% sodium azide|
|AMPK, AMPK2, AMPKa2, PRKAA, 5′-AMP-activated protein kinase catalytic subunit alpha-2, 5′-AMP-activated protein kinase, catalytic alpha-2 chain, AMPK subunit alpha-2, AMPK-alpha-2 chain|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunohistochemistry, Western Blot|
|KLH conjugated synthetic peptide between 145-173 amino acids from the central region of human PRKAA2 (Thr172)|
|Antigen affinity chromatography|
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