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AMPK alpha-2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525987

Catalog No. PIPA525987


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Description

Description

This antibody is predicted to react with mouse, porcine and rat based on sequence homology.

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Specifications

Specifications

AMPK alpha-2
Polyclonal
PBS with 0.09% sodium azide
P54646
AMPK, AMPK2, AMPKa2, PRKAA, 5′-AMP-activated protein kinase catalytic subunit alpha-2, 5′-AMP-activated protein kinase, catalytic alpha-2 chain, AMPK subunit alpha-2, AMPK-alpha-2 chain
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5563
Flow Cytometry, Immunohistochemistry, Western Blot
Unconjugated
PRKAA2
Liquid
PRKAA2
KLH conjugated synthetic peptide between 145-173 amino acids from the central region of human PRKAA2 (Thr172)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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