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PRMT4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141103

Catalog No. 01-675-691


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Description

Description

Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. CARM1 (coactivator-associated arginine methyltransferase-1) also known as PRMT4 (protein-arginine N-methyltransferase-4) belongs to a family of proteins that catalyzes the methylation of arginine residues. The PRMT proteins are recruited by C-terminal activation domain-2 of the SRC (steroid receptor coactivator) GRIP-1, whereas p300 interacts with activation domain-1 in the C terminus. CARM1 can methylate histone H3 in vitro, and a mutation in the putative S-adenosylmethionine binding domain of CARM1 substantially reduces both methyltransferase and coactivator activities suggesting that coactivator-mediated methylation of proteins in the transcription machinery may contribute to transcriptional regulation.

Suggested positive control: Hela whole cell extract, HeLa cell lysate.
Specifications

Specifications

PRMT4
Polyclonal
Unconjugated
CARM1
Liquid
CARM1
Synthetic peptides coorresponding to residues 45-69 and 595-608 of human PRMT4.
Protein G
RUO
Antibody
Polyclonal
Human
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q86X55
PRMT4
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
10498
Documents
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