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proBDNF Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118374

Catalog No. 01-670-626


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Description

Description

This antibody reacts with human, mouse and rat proBDNF and is also expected to recognise other mammalian proBDNF. No cross-reactivity with other proneurotrophins was detected in Western blot. Reconstitute with 20 µL of distilled water. After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent.

BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer ft.s, and Parkinson ft.s disease. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Specifications

Specifications

proBDNF
Polyclonal
Unconjugated
BDNF
Lyophilized
BDNF
Synthetic peptide corresponding to residues (C-E(69) L L D E D Q K V R P N E E(82) of human BDNF precursor.
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry (Frozen), Western Blot
1 mg/mL
Antibody with no preservative
P23560, P21237, P23363
Brain-derived neurotrophic factor, Abrineurin
Rabbit
IgG
20 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Primary
12064, 24225, 627
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