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Progesterone Receptor Mouse anti-Equine, Human, Porcine, Invitrogen™

Antibody Cocktail

Manufacturer:  Invitrogen MA112626

Catalog No. 01-674-010

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MA1-12626 detects Progesterone Receptor in human, equine and porcine samples. MA1-12626 has been successfully used in immunofluorescence, immunoprecipitation, western blot and immunohistochemistry (paraffin, frozen) procedures. The MA1-12626 immunogen is human endometrial carcinoma from in athymic mice.

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintece of pregcy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintece of the endometrium, maintece of pregcy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.


Progesterone Receptor
1 mg/mL
PBS with no preservative
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Equine, Human, Porcine
ChIP assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
hPRa2 + hPRa3
Human endometrial carcinoma from in athymic mice.
Protein G
100033883, 396805, 5241
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