Progesterone Receptor Mouse anti-Equine, Human, Porcine, Invitrogen
Manufacturer: Invitrogen MA112626
MA1-12626 detects Progesterone Receptor in human, equine and porcine samples. MA1-12626 has been successfully used in immunofluorescence, immunoprecipitation, western blot and immunohistochemistry (paraffin, frozen) procedures. The MA1-12626 immunogen is human endometrial carcinoma from in athymic mice.The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintece of pregcy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintece of the endometrium, maintece of pregcy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
|PBS with no preservative|
|PR, NR3C3, PGR|
|-20° C, Avoid Freeze/Thaw Cycles|
|Equine, Human, Porcine|
|ChIP assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|hPRa2 + hPRa3|
|Human endometrial carcinoma from in athymic mice.|
|100033883, 396805, 5241|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok