Progesterone Receptor Mouse anti-Equine, Human, Porcine, Invitrogen™
Manufacturer: Invitrogen MA112626
MA1-12626 detects Progesterone Receptor in human, equine and porcine samples. MA1-12626 has been successfully used in immunofluorescence, immunoprecipitation, western blot and immunohistochemistry (paraffin, frozen) procedures. The MA1-12626 immunogen is human endometrial carcinoma from in athymic mice.The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintece of pregcy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintece of the endometrium, maintece of pregcy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
|PBS with no preservative|
|PR, NR3C3, PGR|
|-20° C, Avoid Freeze/Thaw Cycles|
|Equine, Human, Porcine|
|ChIP assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|hPRa2 + hPRa3|
|Human endometrial carcinoma from in athymic mice.|
|100033883, 396805, 5241|
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