MilliporeSigma anti-Progesterone Receptor Clone: PR4-12,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma GR18100UG
Specifically detects Progesterone Receptor Clone: PR4-12 in Chicken, Feline, Human, Rat samples, and it is validated for Immunohistochemistry (Paraffin)The progesterone receptor (PR) is a member of the superfamily of steroid hormone receptors. In response to ligand binding, these nuclear receptors bind to their target DNA response element and modulate the transcription of specific genes. Hormone induced binding of receptor to its response element promotes the formation of a stable initiation complex, which allows for efficient transcription by RNA polymerase II. Steroid hormone receptors are characterized by a six domain structure labeled A through F. The A/B domain is responsible for trans-activation, C is the DNA binding region and the most highly conserved, D is involved in nuclear localization and E has a variety of functions including ligand binding, dimerization, interaction with HSP90 and trans-activation. There are two forms of the progesterone receptor; the A-receptor (~94kDa) is a naturally occurring, truncated form of the B-receptor (~120kDa). Both forms bind progesterone but may have distinct biological properties. PR is expressed in several tissues especially uterus and breast. PR is one of the most important hormones in the regulation of growth and differentiation in mammary tissue and is thought to play an important role in mammary carcinogenesis. The measurement of PR has become an important prognostic factor in breast cancer and is useful for predicting the likelihood of response to endocrine therapy.
|In 0.05M sodium phosphate buffer, 0.2% gelatin.|
|Recognizes the ∽94kDa progesterone receptor A and the ∽120kDa progesterone receptor B in T47D cells and human breast carcinoma tissue.|
|human progesterone receptor|
|2°C to 8°C|
|Chicken, Feline, Human, Rat|
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