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Progranulin Rat anti-Mouse, Clone: 333731, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524063

Catalog No. PIMA524063


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Description

Description

In direct ELISAs and Western blots, 100% cross-reactivity with Recombinant human Progranulin is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Progranulin is the precursor protein of Granulin also called as Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature Granulin. Both Granulin and smaller cleavage product of Granulin regulates cell growth. Progranulin stimulates proliferation of many epithelial cells, promotes their anchorage-independent growth and, when overexpressed, confers epithelial tumorigenicity. Progranulin/epithelin gene is multifunctional, with important constitutive roles in epithelial homeostasis, reproductive, immunological, and neuronal function. Progranulin constitutively expressed in a number of epithelia, particularly in the skin, GI tract, and reproductive system. Progranulin is expressed in immune cells in vivo and in specific neurons in the brain.
Specifications

Specifications

Progranulin
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P28798
Granulin, PEPI, CLN11, GEP, GP88, PCDGF, PGRN, Acrogranin, Granulin-epithelin, PC Cell-derived growth factor, Proepithelin
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
14824
Immunohistochemistry (Frozen), Western Blot
333731
Unconjugated
Grn
Lyophilized
GRN
Mouse myeloma cell line NS0-derived recombit mouse Progranulin/PGRN Thr18-Leu589
Protein A/G
RUO
Antibody
Monoclonal
Mouse
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