Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

PSME2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1976

Catalog No. PA1976


Add to cart

Description

Description

PA1-976 detects recombit human and mouse proteasome 11S REG beta. This antibody does not detect endogenous levels of proteasome 11S REG beta nor does it detect other 11S REG subunits. PA1-976 has been successfully used in Western blot and ICC/IF procedures. By Western blot, this antibody detects an ~28 kDa protein representing recombit human proteasome 11S REG beta. PA1-976 immunizing peptide corresponds to amino acid residues 1-14 from human proteasome 11S REG beta protein. This peptide (PEP-158) is available for use in neutralization and control experiments.

Proteolytic degradation is critical to the maintece of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
Specifications

Specifications

PSME2
Polyclonal
Unconjugated
PSME2
Liquid
PSME2
Synthetic Peptide: M(1) A K P C G V R L S G E A R(14)
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.05% sodium azide
Q9UL46, P97372
PA28B, PA28beta, REGbeta
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
19188, 5721
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit