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PSMC5 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1970

Catalog No. PA1970

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum.The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

PA1-970 detects proteasome 19S subunit S8 from human cells.PA1-970 has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a 45kDa protein representing proteasome 19S subunit S8 from HeLa cell lysate.PA1-970 antigen is recombinant proteasome 19S subunit S8.
Specifications

Specifications

PSMC5
Polyclonal
PBS with 1mg/mL BSA and 0.05% sodium azide
P62195
S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5705
Immunoprecipitation, Western Blot
Unconjugated
PSMC5
Liquid
PSMC5
Human recombit proteasome 19S subunit S8.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human
Documents
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