Protein C Rat anti-Mouse, Clone: 9072, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA143032
MA1-43032 detects Protein C in mouse samples. MA1-43032 has successfully been used in Western blot and ELISA applications. MA1-43032 was derived from mouse protein C.Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 µg/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulmis, and recurrent venous thrombosis.
|50%water with 50% glycerol and no preservative|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|Mouse protein C.|
|Ammonium sulfate precipitation, Ion-exchange chromatography|
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