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Protein C Sheep anti-Human, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA143051

Catalog No. PA143051


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Description

Description

PA1-43051 detects Protein C in human samples. PA1-43051 has successfully been used in Western blot and ELISA applications. PA1-43051 was derived from human protein C.

Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 µg/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulmis, and recurrent venous thrombosis.
Specifications

Specifications

Protein C
Polyclonal
Unconjugated
PROC
Liquid
PROC
Human Protein C.
Ammonium sulfate precipitation, Ion-exchange chromatography
RUO
Antibody
Polyclonal
Human
ELISA, Western Blot
8.6 mg/mL
50%water with 50% glycerol and no preservative
P04070
PROC
Sheep
IgG
1 mg
-20° C, Avoid Freeze/Thaw Cycles
Primary
5624
Documents
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