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PP2CA/PP2CB Rabbit anti-Bovine, Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112395

Catalog No. 01-674-128


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Description

Description

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Specifications

Specifications

PP2CA/PP2CB
Polyclonal
PBS with 0.08% sodium azide
O62829, O62830, O75688, P35813, P36993, P49443, P20650, P35815
FLJ42306, MGC9201, PP2C-ALPHA, PP2CA, PP2Calpha
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
19042, 19043, 24666, 24667, 281994, 281995, 5494, 5495
Western Blot
Unconjugated
PPM1B
Liquid
PPM1A, PPM1B
Synthetic peptide.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Bovine, Human, Mouse, Rat
Documents
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