PPP4C Rabbit anti-Bovine, Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112401
DescriptionProtein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.
|PBS with 0.08% sodium azide|
|A6H772, P60510, P97470, Q5BJ92|
|PP4, PP4C, PPH3, PPP4, PPX|
|-20° C, Avoid Freeze/Thaw Cycles|
|171366, 540398, 5531, 56420|
|Immunocytochemistry, Western Blot|
|Ammonium sulfate precipitation|
|Bovine, Human, Mouse, Rat|
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