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PPP4C Rabbit anti-Bovine, Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112401

Catalog No. 01-674-134


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Description

Description

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.
Specifications

Specifications

PPP4C
Polyclonal
PBS with 0.08% sodium azide
A6H772, P60510, P97470, Q5BJ92
PP4, PP4C, PPH3, PPP4, PPX
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
171366, 540398, 5531, 56420
Immunocytochemistry, Western Blot
Unconjugated
PPP4C
Liquid
PPP4C
Synthetic peptide.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Bovine, Human, Mouse, Rat
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