SHP2, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA138602
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified.Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is bone marrow tissue.
|PBS with 1% BSA and <0.1% sodium azide; pH 7.6|
|Q06124, P35235, P41499|
|4° C, do not freeze, do not freeze|
|19247, 25622, 5781|
|Synthetic peptide corresponding to aa 576-593 of human SH-PTP2 protein|
|Antigen affinity chromatography|
|Human, Murine, Rat|
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