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SHP2, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA138602

Catalog No. 01-673-728

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified.

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is bone marrow tissue.
Specifications

Specifications

SHP2
Polyclonal
PBS with 1% BSA and <0.1% sodium azide; pH 7.6
Q06124, P35235, P41499
PTP1C, HCP
Rabbit
IgG
1mL
4° C, do not freeze
Primary
19247, 25622, 5781
Immunohistochemistry (Paraffin)
Unconjugated
PTPN11
Liquid
PTPN11
Synthetic peptide corresponding to aa 576-593 of human SH-PTP2 protein
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Murine, Rat
Documents
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