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PCDHGA2 Mouse anti-Human, Mouse, Clone: 2A7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA522250

Catalog No. PIMA522250


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Description

Description

Peptide Sequence: SGTSRICVKV LDANDNAPVF TQPEYRISIP ENTLVGTRIL TVTATDADEG YYAQVVYFLE KSPGETSEVF ELKSTSGELT IIKDLDYEDA TFHEIDIEAQ DGPGLLTRA

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Specifications

Specifications

PCDHGA2
Monoclonal
1.0 mg/mL
PBS with no preservative; pH 7.4
Q9Y5H1
PCDHGA2
PCDHGA2 (NP_061738, 223 a.a. ∽ 331 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Protein A
RUO
Antibody
Monoclonal
Human, Mouse
ELISA, Western Blot
2A7
Unconjugated
PCDHGA2
Liquid
Mouse
IgG2a, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
56113, 93710
Documents
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