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PrP Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA136137

Catalog No. 01-672-293


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Description

Description

Reconstitute with 50-100 µL of distilled water, and dilute further in 0.1M PBS with 1% BSA and 0.1% sodium azide.

Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
Specifications

Specifications

PRP
Polyclonal
whole serum with 0.1% sodium azide
P13852
PrP, Prn
Rabbit
IgG
RUO
Antibody
Polyclonal
Rat
Immunofluorescence, Immunohistochemistry (Frozen)
Unconjugated
Prnp
Lyophilized
PRNP
Synthetic rat PRP conjugated to BSA. Tested on rat tissues.
50 μL
4° C
Primary
24686
Documents
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