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PRR5L Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521129
A suggested positive control is NIH-3T3 cell lysate. PA5-21129 can be used with blocking peptide PEP-1243.Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.
|A 17 amino acid peptide near the center of human PRR5L.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|PROTOR2; Protein observed with Rictor-2; proline-rich protein 5-like; protor-2|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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