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PRR5L Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521129

Catalog No. PIPA521129



Description

Description

A suggested positive control is NIH-3T3 cell lysate. PA5-21129 can be used with blocking peptide PEP-1243.

Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.
Specifications

Specifications

PRR5L
Polyclonal
Unconjugated
PRR5L
Liquid
PRR5L
A 17 amino acid peptide near the center of human PRR5L.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q6MZQ0, A2AVJ5
PROTOR2; Protein observed with Rictor-2; proline-rich protein 5-like; protor-2
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
72446, 79899
Documents
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