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PRTFDC1 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520593

Catalog No. PIPA520593


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-20593 can be used with blocking peptide PEP-0713.

Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
Specifications

Specifications

PRTFDC1
Polyclonal
Unconjugated
PRTFDC1
Liquid
PRTFDC1
A 14 amino acid peptide from near the center of human PRTFDC1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9NRG1
HHGP; phosphoribosyltransferase domain-containing protein 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
291355, 56952
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