PRTFDC1 Rabbit anti-Human, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520593
A suggested positive control is human brain tissue lysate. PA5-20593 can be used with blocking peptide PEP-0713.Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
|A 14 amino acid peptide from near the center of human PRTFDC1.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|HHGP; phosphoribosyltransferase domain-containing protein 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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