PSEN1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.

Manufacturer:  Abnova Corporation PAB12993

Catalog No. 89-116-248

Description

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq

Specifications

• Antigen: PSEN1
• Conjugate: Unconjugated
• Dilution: Western Blot (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: PSEN1
• Gene Alias: AD3|FAD|PS1|S182
• Host Species: Rabbit
• Quantity: 100 ug
• Storage Requirements: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Monoclonal or Polyclonal: Polyclonal
• Test Specificity: This antibody has no cross-reactivity to presenilin2.

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Description: Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.
• Formulation: In PBS (0.02% sodium azide)
• Format: Liquid
• Gene Symbols: PSEN1
• Immunogen: A synthetic peptide corresponding to C-terminus 23 amino acids of human PSEN1.
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5663
• Target Species: Human, Murine, Rat

For Research Use Only