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PSME1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525179

Catalog No. PIPA525179


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Description

Description

This antibody is predicted to react with bovine, mouse, porcine, non-human primate and rat based on sequence homology.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring.
Specifications

Specifications

PSME1
Polyclonal
PBS with 0.09% sodium azide
Q06323
IFI5111, PA28A, PA28alpha, REGalpha, 11S regulator complex alpha subunit, 11S regulator complex subunit alpha, 29-kD MCP activator subunit, IGUP I-5111, REG-alpha, activator of multicatalytic protease subunit 1, interferon gamma up-regulated I-5111 protein, interferon-gamma IEF SSP 5111, interferon-
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5720
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
PSME1
Liquid
PSME1
KLH conjugated synthetic peptide between 220-249 amino acids from the C-terminal region of human PSME1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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