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PTEN, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527304

Catalog No. PIPA527304

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

PA5-27304 targets PTEN in IF, IHC(P) and WB applications and shows reactivity with Human and mouse samples.The PA5-27304 immunogen is recombinant protein fragment corresponding to a region within amino acids 182 and 376 of Human PTEN.
Specifications

Specifications

PTEN
Polyclonal
Unconjugated
PTEN
Purified
PTEN
Recombinant protein fragment corresponding to a region within amino acids 182 and 376 of Human PTEN
Antigen affinity chromatography
Store at -20°C, Avoid Freeze/Thaw Cycles
Primary
5728
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1mg/mL
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
P60484, O08586
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, MMAC1, TEP1, Phosphatase and tensin homolog
Rabbit
IgG
100μL
Antibody
Polyclonal
Human, Murine
Documents
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