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PTGDS Rabbit anti-Bovine, Equine, Feline, Human, Mouse, Non-human primate, Porcine, Rabbit, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA146022

Catalog No. PA146022


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Description

Description

This antibody has an 87% sequence homology with ovine and a 82% homology with rabbit. Suggested positive control: antigen standard for PTGDS (transient overexpression lysate), human brain protein.

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintece of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintece of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer’s disease.
Specifications

Specifications

PTGDS
Polyclonal
Unconjugated
PTGDS
Liquid
PTGDS
A synthetic peptide made to a region within residues 25-100 of the human PTGDS protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Equine, Feline, Human, Mouse, Non-human primate, Porcine, Rabbit, Rat
Western Blot
1 mg/mL
PBS with 30% glycerol and 0.1% sodium azide
O02853, Q9XS65, O97921, Q29487, P41222, O09114, Q29095, P22057
Lipocalin-type prostaglandin-D synthase , L-PGDS , Glutathione-independent PGD synthetase , Prostaglandin-
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100067921, 19215, 25526, 286858, 397456, 403740, 493852, 5730
Documents
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